Efficacy and Safety of Rosuvastatin versus Atorvastatin in the Treatment of Ischemic Stroke: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials

Main Article Content

Kaiwen Cui
School of Health Management, Anhui Medical University, Hefei 230032, China

DOI: https://doi.org/10.70267/shbe.20263447

Keywords

ischemic stroke, statins, rosuvastatin, atorvastatin, meta-analysis

Abstract

This study aimed to compare the efficacy and safety of rosuvastatin and atorvastatin in the treatment of ischemic stroke. Literature published before January 1, 2026 was retrieved from five databases, including PubMed, Web of Science, CNKI, Wanfang , and VIP. Eligible studies were screened according to the predefined inclusion and exclusion criteria. The included studies were comprehensively analyzed based on the primary outcome measures of blood lipid parameters, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL -C), and total cholesterol (TC), as well as the secondary outcome measures of carotid atherosclerosis, including intima -media thickness (IMT) and plaque area, together with the neurological deficit score assessed by the National Institutes of Health Stroke Scale (NIHSS). A total of 12 randomized controlled trials were included in the final analysis. The results showed that, compared with atorvastatin, rosuvastatin demonstrated superior effects in r educing blood lipid levels and improving carotid IMT and NIHSS scores. Overall, rosuvastatin exhibited better clinical efficacy in the treatment of ischemic stroke. Although both agents showed broadly comparable effects in lipid lowering, stabilization of carotid atherosclerotic plaques, and improvement of neurological function, rosuvastatin appeared to have a more favorable safety profile than atorvastatin. Nevertheless, further multicenter, large -scale, high -quality randomized controlled trials are still required to confirm its efficacy and safety.

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References

  • [1] Cheng, X. Y. (2025). Regulatory effects of the non-classical NF-κB pathway on cortical collateral vessels after ischemic stroke [Master’s thesis, Southern Medical University]. https://link.cnki.net/doi/10.27003/d.cnki.gojyu.2025.001554
  • [2] Cheng, X., Ye, J. X., Lin, H., & Mu, J. S. (2011). Research progress on neuroprotective mechanisms of statins in patients with ischemic stroke. Chinese Journal of Cerebrovascular Diseases, 8 (07), 388–392. https://kns.cnki.net/kcms2/article/abstract?v=W- y7fKBVJCzOGvTXD0jxzsblVhINwPvdthnq9RtgkajukIW96P1C4dldmIkfT6vFyuTkSEch7u7xxHGFi Ky25ECOoHmRAMeqBIhikQnDMRQGLeJ9xX_PlpBr7wFwUQfvrV1W0uP523Hzf2KUu3Ka2C- ngzrWLmQz-Uza_7lsAjR6PClCC_xEZQ==&uniplatform=NZKPT&language=CHS
  • [3] Guo, G. Y., & Xu, S. S. (2016). Clinical observation of rosuvastatin and atorvastatin in the treatment of ischemic stroke. China Medical Guide, 14 (32), 152 –153. https://doi.org/10.15912/j.cnki.gocm.2016.32.131
  • [4] Guo, J., Lv, Y. F., Lin, C. Y., & Wang, Y. N. (2018). Comparative study on the efficacy and safety of intensive lipid -lowering therapy with rosuvastatin and atorvastatin in acute cerebral infarction. Community Medicine Journal, 16(4), 18–20.
  • [5] Guo, L. W. (2025). Correlation between LDL-C target achievement in dyslipidemia patients before and after the release of the “China Guideline for Lipid Management (2023)” and efficacy and safety analysis of PCSK9 inhibitors [Master’s thesis, Inner Mongolia Medical University]. https://link.cnki.net/doi/10.27231/d.cnki.gnmyc.2025.000139
  • [6] Guo, X. H., & Hu, B. N. (2022). Therapeutic value analysis of atorvastatin and rosuvastatin in patients with transient ischemic attack. Chinese Community Physician, 38 (4), 37 –39. https://doi.org/10.3969/j.issn.1007-614x.2022.04.013
  • [7] Hu, W. J., & Zhang, Q. X. (2020). Medication analysis and pharmaceutical monitoring of a patient with atrial fibrillation combined with myocardial infarction using high -intensity atorvastatin and amiodarone causing rhabdomyolysis. China Drug Application and Monitoring, 17 (05), 313 –316. https://kns.cnki.net/kcms2/article/abstract?v=W-y7fKBVJCxpaA-r1PGPDhGTZ1toCXiRSk- qaI2qQMW5E2F2I3SnjSFQTz8l- KnzPhpx9i6qsUR7kSPB4LajF1Rbv3yzHnzrfITpNeUhEUyYg46hvBCuCgOJxG947dQSgbV2QywsLv gaYnYx- Smk2nainA40_iFlWQyJUx6IRjy4nQdqkbIEI9SA8bstyc81&uniplatform=NZKPT&language=CHS
  • [8] Hu, Y. Y. (2018). Comparative study on the efficacy of rosuvastatin and atorvastatin in treating ischemic cerebrovascular disease and their impact on patient quality of life. Clinical Rational Drug Use, 11(7), 56– 57. https://doi.org/10.15887/j.cnki.13-1389/r.2018.07.028
  • [9] Hu, Y., Zheng, J., & Chen, X. (2025). Efficacy and safety of rosuvastatin versus atorvastatin in the treatment of acute myocardial infarction in severe coronary atherosclerotic heart disease. Systematic Medicine, 10(14), 102–105+118. https://doi.org/10.19368/j.cnki.2096-1782.2025.14.102
  • [10] Huang, X. Y. (2025). Classification and prognosis study based on multidimensional characteristics of ischemic stroke patients [Doctoral dissertation, Peking Union Medical College]. https://link.cnki.net/doi/10.27648/d.cnki.gzxhu.2025.001184
  • [11] Huang, Y. Q., Dong, Y. R., Huang, X. T., & Bai, B. Q. (2025). Effects of evolocumab combined with atorvastatin on blood lipids and prognosis in patients with multivessel coronary artery disease. Heilongjiang Medical Science, 48 (12), 81 –82+85. https://kns.cnki.net/kcms2/article/abstract?v=W- y7fKBVJCxuQ5Zf2- TMudg63JUSZRSR_dQCJF01zezoXEGoYv47JDtuAR0DRFkFTaHHZjI_jjXevBr3QTH- hCNX8Y2p6zU0XtCaIdmWw_Sqa- JDfLnwo37tdVCrNLs7cFUY7O7CRmtKaOcl2l9zXKxvUv7bA8atvMa_SlPaZtMOE1lCVv7a81Cwr13 0_dhT&uniplatform=NZKPT&language=CHS
  • [12] Jiang, L. J. (2021). Comparative analysis of clinical efficacy of rosuvastatin and atorvastatin in treating transient ischemic attack. Chinese Science & Technology Journal Database (Full -text Edition) Medical & Health, 10, 012–013.
  • [13] Li, J. J., He, W., & Guo, Q. (2020). Meta -analysis on the efficacy of different doses of rosuvastatin in Chinese patients post-PCI for acute myocardial infarction. Drug Evaluation Research, 43(07), 1406–1413. https://kns.cnki.net/kcms2/article/abstract?v=W-y7fKBVJCxpaA-r1PGPDhGTZ1toCXiRSk- qaI2qQMW5E2F2I3SnjW6wKVvZAwAv8cEDJ_7Ve7I9MgpzHKRSwgonu3OnlrTg4U7K0UTWaw6 TZLIEZ9GqESB7LtfCPkk4AtDUXlK2ZX-vT5_Ck4RP7tEFRvM0XhAzVDCjgH- XWSgOHTUyod5w_D-9XcYk4pP4&uniplatform=NZKPT&language=CHS
  • [14] Liu, D., & Zhang, G. Z. (2026). Effects of rosuvastatin on blood lipids and vascular endothelial function in patients with coronary heart disease and hyperlipidemia. Modern Medicine and Health Research E - Journal, 10 (01), 135 –137. https://kns.cnki.net/kcms2/article/abstract?v=W- y7fKBVJCxRonZeJR4LYmk80x5Nm3oPV3uEcz26UWqwmVzZbl9-xHNUPD_pGWWs- iN1LGS_o0JtAmPb-SNEZkhpTIOts3DhoKosYQzFvmAF0tlq2smF71bi31uBNPa4F3- qka7U7ZtmfO6Vd9Hp_n5NX- ZMFbOELySrYk8_vKhJFKsufRuFtQ==&uniplatform=NZKPT&language=CHS
  • [15] Liu, L., Bao, Z. J., Zhou, D., Jiang, L., & Wang, J. (2021). Comparative efficacy of rosuvastatin and atorvastatin on depressive symptoms in elderly patients with atherosclerotic cerebral infarction: Observations in atherosclerotic cerebrovascular disease. Youjiang Medical Journal, 49 (9), 668 –672. https://doi.org/10.3969/j.issn.1003-1383.2021.09.006
  • [16] Luo, J. (2022). Brief discussion on efficacy evaluation of atorvastatin and rosuvastatin in patients with ischemic stroke. Chinese Science & Technology Journal Database (Full-text Edition) Medical & Health, 5, 50–53.
  • [17] Ou, Y. (2024). Analysis of efficacy and adverse reactions of atorvastatin and rosuvastatin in patients with ischemic stroke. China Science & Technology Journal Database Medical, 7, 53–56.
  • [18] Qiu, S. J. (2020). Comparative study on the efficacy of rosuvastatin and atorvastatin in patients with acute cerebral infarction. Contemporary Medicine, 26 (6), 152 –153. https://doi.org/10.3969/j.issn.1009 - 4393.2020.06.061
  • [19] Expert Consensus on Prevention and Treatment of Ischemic Stroke/Transient Ischemic Attack with Statins. (2013). Chinese Journal of Stroke, 8 (07), 565 –575. https://kns.cnki.net/kcms2/article/abstract?v=W- y7fKBVJCwtSlPosC95XXdfZ5B9Jmp6eVbvUTuwlC71rugwTUxZEkHqI0K- aCdCdxk4t1Nr7BA8AOlkS4ExxdffP7qo9JRB6RdJHgAD8iPZZV5lBn1McwjbMccpWL37LCf4Su- yzFhYgRyMwoDRtFJL7awXCcLPGLZy8r9zLESR7fQ_y9nNxA==&uniplatform=NZKPT&language =CHS
  • [20] Wang, C. B. (2022). Evaluation of efficacy and adverse reactions of atorvastatin and rosuvastatin in patients with ischemic stroke. Chinese Science & Technology Journal Database (Citation Edition) Medical & Health, 7, 24–26.
  • [21] Wang, H. J. (2020). Analysis of lipid -lowering effects of atorvastatin and rosuvastatin in patients with ischemic stroke. China Modern Drug Application, 14 (22), 82–84. https://doi.org/10.14164/j.cnki.cn11- 5581/r.2020.22.038
  • [22] Yang, C. Y., Zhang, X. Q., Chen, Z. W., & Feng, Z. (2016). fMRI study of high -frequency repetitive transcranial magnetic stimulation for unilateral spatial neglect in stroke patients. Chinese Journal of Rehabilitation Medicine, 31 (10), 1088 –1093. https://kns.cnki.net/kcms2/article/abstract?v=W- y7fKBVJCx-0bI37dLgBzmIcNRrRRP0of-97w3NYqf9rdwDcqf9VsoSBn1RP4yamKW- cvNsz4FOVbYNJ0rxW2O03nNKITqNYwWd1kqXYQwquR0X9gZ25bgrLXNl3boL7PuGy4Yjzm2Es 6dWMyvjTyJVTxQ20aTj6aHPMoYlnGgygewTwTsM_MFfm8PFQuwy&uniplatform=NZKPT&langu age=CHS
  • [23] Yao, L. N., Li, M. J., Wang, Y. Z., Yang, Y. H., Che, Y. N., Sun, X. Y., Ning, W., Yue, S. Y., Guo, S. Q., & Zhang, L. N. (2018). Effects of rosuvastatin and atorvastatin on blood lipids and carotid atherosclerotic plaques in patients with acute cerebral i nfarction. Journal of Integrated Traditional Chinese and Western Cardiovascular & Cerebrovascular Diseases, 16 (24), 3714 –3717. https://doi.org/10.12102/j.issn.1672-1349.2018.24.042

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Published
Aug 11, 2026
Conference Proceedings Volume
Vol. 18 (2026): Proceedings of 2026 International Conference on Smart Healthcare and Biomedical Engineering (ICSHBE 2026)
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Articles
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How to Cite

Cui, Kaiwen. “Efficacy and Safety of Rosuvastatin Versus Atorvastatin in the Treatment of Ischemic Stroke: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials”. Exploring Science Academic Conference Series, vol. 18, Aug. 2026, pp. 34-47, https://doi.org/10.70267/shbe.20263447.